Many scientists regard selective nuclear transport of RNAs as a form of genetic regulation in eukaryotes. The discovery of what appears to be an array of nuclear fibrous elements adds to that appeal. In a recent literature review (Pederson, 2000. Molecular Biology of the Cell 11: 799-805), the author reported data arising from various labeling experiments designed to determine whether gene regulation in eukaryotes is related to nuclear sorting of pre-mRNAs. The vast majority of the results indicated that nuclear poly-A RNA moves by diffusion. What influence would these results have on models that relate gene regulation to nuclear RNA transport?
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