Question

• Describe childhood acute lymphocytic leukemia (ALL) and G6PD deficiency and the incidence, pathophysiology, clinical manifestations, evaluation, and treatment of each.

Answer 1

Acute is Acute lymphocytic leukernia CALLD Incidence Rare fewer than 1 million cases per year Pathophysiology:- A cette lymphocytic leukemia Occino When a bone marrow cell develops erroos in its DNA .. The bone marrow Prodyles immature rells that develop into leukemic white blood cells called. lymphoblasts. These abnormal cells are unable to function properly and they can build up and crowd out healthy cells. Clinical menifestations pain areas in the bone Whole body - fatigue fever, loss of appetite or night sweats Also common - bleeding gums, easy bruising infection, nosebleed, pallor, red spot- on skin, shortness of breath, Swollen lymph nodes or wt loss 1 Treatment - Treatments not include chemotherapy or targeted drugs that specifically Kill cancer cells. IV fluüds. Nutrition -

GERD. Deficiency: A Couton c sin_ud blood cells to bxed down in response to certall medication, infectiony for other stress Incidence - common: More than 1 million cases pea year) Male it more affected than female Pathophysiology - G6PD deficiency B a common, x. linked reduction in the activity of gucose-6-phosphate dehydrogenase (G6PD), which mako erythrocytes Isusceptible to oxidative stress and usually laulses coulte hemolytic anemia in response to la "trigger" G6PD enzyme deficiency is the most common enzyme defed clinical Menifestations: can have no symptoms, but people may. experience, - pain in abdomen or back lanemia or fatigue daak urine, pallar or yellow skin and eyes -Treatment - Most require supportive treatment like - frechtment for hemolytic anemia Removal and avoidance of further triggers. -1 severe hemolysts_blood testisions my be required. - His may be needed it acute kidney injury. occum I Prognosis is good.