Question

Нeme Provide a detailed drawing of the prosthetic group Heme and a detailed explanation of its role in myoglobin and hemoglobin function. Cooperativity Provide a detailed explanation (with figures) of the cooperative binding of oxygen by hemoglobin. Bohr Effect Provide a detailed explanation (with figures) of the phenomenon known as the Bohr Effect Hemoglobin Mutants Provide a detailed explanation (with figures) of the relationship between a hemoglobin mutant and disease,

Answer 1

CH2 00H sold This is home containing Fell Because of the presence of fe atom in the heme group, it gives myoglobin & hemoglobin, the ability to bind oxygen. Myoglobin contains one group home group & is responsible for storage of o₂, Whereas Hemoglobin contain four such neme group 4 con bind e o atom at a time 4 is responsible for transport of oxygen. myoglobin on hemoglobin has Deoxygenated home containing Fe in t2 oxidation state. Fe 2+ size is too largest to fit in the home group so it sits outside the ring by 0.4 A Upon oxygenation. Fe2f is converted to Feat & O₂ converted to superoxide, Fe 3+ size is smaller than Fezt & fits into the ring which is pulled by the superoxide attached to rest in one side a phoxinual histidine nedidone on other side