
Simple synthesis using like THF, H2O, NaCl, NaBr , DMSO
etc..
OH
Please break up the reactions into the 3 separate balanced
chemical equations.
HN HN HN HN HNO3 H2SO4 NO2 + Dinitro- products "NO2 N-Acetylaniline (Acetanilide) MW = 135 g/mol NO2 NH2 Acid Hydrolysis Dinitro- products NH3 НО + Dinitro- products NO2 > NOZ Mononitroanilines MW = 138 g/mol TNH3 NH2 Acid Hydrolysis H2O Neutralizing the amino group + NH+ -NO₂ NH3 NO2 NO2 H2SO4 H2O Mononitroanilines MW = 138 g/mol N-Acetylnitroanilines OH
1. Determine if E1 or E2 and the product formed. H₂O H2O t-butoxide DMSO OCH 3 CHONa. DMSO -ochz Br CHOU CHOH OH acetic acid ОН 2. Draw all the possible products. OH
Draw all stereoisomers formed in each reaction. o . outro od NBS DMSO, H20 H2O H2SO4
B) Propose a mechanism of the following reaction (enamines are like enols, but more reactive). 1)DMSO/H2O/Cat H30 1.0 equiv Br2 I Br
Which conditions are optimum for an E2 reaction? DMSO a) CH31 100 Divo DMSO CH CH3 b) CH3CHCI + CH,COK CH CH3 c) CHICHCH2Cl + CH OH H2O HO CH3 d) CH3CHCH2Br + CH,8 oooo
help explain pls
NaCN DMSO TsCI pyridine OH MsCI pyridine NasMe DMSO cat. HA MeOH g. Arrange in the Increasing acidity order H2O ROH RC=CH HẠ NH RH
Which of the following compounds are H2O soluble? OH HAN OH NH2 OH HN ОН A B с ΑΙΑ B CIC PA and B E B and C FA and C G A, B, and C
Ochem 2 ch 22
Chemistry 2320 Ch 22 Amines (100 pts) h) HN CH2CI2 i) 1) KOH/DMF H2NNH2 N-H E1OH 2) CI NaN3 LAH THF k) NaCN LAH THF DMSO I) HONO2 H2/Ni CH3OH H2SO m) 1) SOCI2 /pyr LAH THF NH2 2) n) H2/ Ni NH2 CHO+ CH-он o) H* (cat) NABH3CN NH2 -H2O CHОH Page 6 of 8
12. (5) Draw the mechanism for the following reaction. NaOHCoH402 DMSO OTs