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Chapter 38- Sulfamethoxazole-trimethoprim Amoxicillin & Ampicillin; Penicillin V (PO); Penicillin G (IM, IV) Penicillirn Antibiotic name Drug Class & Indications Contraindications Sulfa Common Adverse Effects Major Interactions ex. CYP450 Nurse Considerations: (Examples: Age, renal/hepatic precautions, safety with administration, lab monitoring teaching)

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SULFA (indication - Bacterial infection)

Contraindication- allergic to Aspirin related drugs

G6PD deficiency

Asthma

Aplastic anemia

Porphyria

Adverse effect- Stomach upset

Nausea, vomiting

a severe headache

Yellow urine

Unusual tiredness

temporary infertility

sensitivity to light

Interaction- Digoxin

Folic acid

Methenamine

PABA

Nurse consideration - this drug is similar to Mesalamine, so do not use it together

this drug may interfere in some lab test like urine normetanephrine level and can give a false result

Penicillin (Indication- Bacterial infection)

contraindication- this drug passes into breast milk, it can cause the side effect in newborn

adverse effect- joint or muscle pain

vision changes

changes in the amount of urine

joint swelling

interaction- warfarin

NSAIDS

Methotrexate

Nurse consideration - medical history like asthma, kidney disease

it can causes live vaccines inactive

can increase pottasium level

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