Question

You are treating two different patients with the same disease. You prescribe the same treatment to both patients at the same dose and frequency. While patient A shows vast improvement in their symptoms, patient B remains the same and shows no sign of improvement. What could explain this difference in response? Patient A could have decreased receptor expression for the molecular target on the tissue of interest Patient B could be a poor metabolizer and so the metabolism of the drug is decreased in this patient Patient B could be older and have decreased signalling produced by the molecular target after drug binding Patient A could have a higher clearance of the drug

Answer 1

Answer would be , patient B could be older and have decreased signalling produced by the molecular target after drug binding.

Drug action is different for different person even if drug is same. Maybe due to chemical pathway in the body , metabolic rate,age, Genetics etc