Question

Could you help with #2,4,3,6, please

1. Define the term "Nucleophile" and explain how a Grignard reagent acts as a nucleophile. Briefly explain using a chemical equation, why it is necessary to use dry apparatus and reagents during the synthesis of C6H5MgBr. phenylmagnesium bromide. 3. By referring to a textbook, write a mechanism for the reaction between phenylmagnesium bromide and the ketone butanone. In a reaction of phenylmagnesium bromide with butanone the Grignard reagent was prepared from 25 g of bromobenzene and was then treated with a solution of 10 g of the butanone in 50 mL of ether that contained 1% by volume of water. Calculate the amount of benzene (in g) that would be produced and the maximum theoretical yield of tertiary alcohol corrected for loss due to benzene formation 5. List those steps in the experimental procedure that may likely lead to the most significant loss in the yield of the final product. 6. If methyl benzoate were unavailable, what ketone might be used to prepare triphenylmethanol, using phenylmagnesium bromide as a Grignard reagent?

Answer 1

2. Phenylmagnesium bromide (C6H5MgBr) is a grignard reagent (RMgX) and is very reactive . It readily reacts with water and get converted into hydrocarbon as follows ;

C6H5MgBr + H2O >>>>>>> C6H6 + Mg(OH)Br

Thus yield of grignard reagent will be reduced by wet apparatus (having water droplets) .

To avoid this , the apparatus should be dry for the synthesis of grignard reagent.