Question

Write research about ”Epidermolysis bullosa (EB)” with introduction and the Meachism of action for this disease and the treatment with the mechanism of action with reference.

Answer 1

heterogenous skin induced skin demolysis bulloso is a clinically and genetically, inous skin fragolety disordu chavaitéised by trauma Led skin dissociation and the development of inful wounds. So fa meitations in 20 genes have var cisceibed as being auociated with mou than 30 clinical ED subtypes. With advances of gene editing ,maie focus has been. placed on gene editing - based Shecapies. fpe targeted treatment has be i der Unfortunately the treatment for individials with EB is still symptomatic with implementation of moden wound care and treatment of disease ausocialed complicalog In 2006, an Italian research group was successful in achieving long term engraftment of epidermal sheets genceated from exvivo, gene collected, autologous epideemal stem celle from a patent with JEB caused doy LAMB3. huetation's DE B is caused by mutations in collagen Vil gene COLFA, d characterized by blistering at subliminal densa . Transplaktation of epideeris genuated from exvivo couected cut dogous Keratinocytes has also shown promise ina - clinical trial for treatment of choic wounds

Additional Appunches using either allogeneic wild type bone mauow decived istem cells Ok autologous. spontaneously wuected epidermal stem cells, egin ieveétant mosaic patches are possible therapeutic stiãtenie that would not segule gene engineeeing I is expected that more focus will be placed on gene editing-based thecopies fore. targeted treatment thwevee their implementation in daily cale will stu take timely into → TGF-B signaling activity is a major detteminant of disease severity in DTB ... dones Freethe safe and efficient molecules more disedly lasgeting TAF-B activity are crucently und precērical testing - Biological producte au also able to act as disease ridi modifice - Polent agenta - Mesenchymal stromal celle (MSC) - disease -cunseliceating duegs in EB because of their strong antiinflammalay abilities We Since these cella alę also natual peoduces of collagen in given at a sufficient dose , they may also testove peotein abundance et deemo-epidermal Junction . S zone