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1.Mechanism of action of a drug is the biochemical reaction through which a drug produce its maximum effect in the body or target tissue. The very basic and simple chemical reaction of a drug is interaction with receptors by bonding at specific binding sites
For example,Salbutamol used for bronchial smooth muscle relaxation.
Salbutamol specifically stimulate the beta 2 adrenergic receptors seen in bronchial smooth muscles which leads to activation of adenyl cyclase enzyme. This helps to form cyclic adinosine -mono -phosphate(cAMP)from adenosine- try -phosphate (ATP). The increase in the level of cAMP leads to bronchial smooth muscle relaxation and inhibit the release of bronchoconsrictor mediators from mast cells seen in the airway as well as decrease the airway resistance by lowering calcium levels in intracellular fluid.
2.Affinity of a drug is the strength of binding between a drug and its receptor which is influenced by drug molecule size,drug molecule shape, bonding- forces between drug and binding sites, Stereochemistry ( types, number, and spatial arrangement of drug)
Specificity of a drug is the ability of a drug to interact specifically to particular receptors or bind to a single receptor because to its structure is specific to particular receptor binding site. Drugs are classified into specific and non specific according to their specificity.
Provide one example of a medication and explain the mechanism of action of a medication which...
Describe the chemical differences between strong and weak acids. Give an example of each, and provide the pH of each example. (3 points) Describe the chemical differences between strong and weak bases. Give an example of each, and provide the pH of each example. (3 points) In your own words, describe the difference between an inorganic and organic compound. (1 point) Give an example of one inorganic substance and: (1 point) Write the chemical formula for it and write out...
Describe the mechanism of action and target one of the classes of antibiotics discussed in lecture. Provide a specific example of an antibiotic that falls under the chosen class and describe one way that resistance occurs within the microbial population. Briefly describe why microorganisms produce antibiotics in the environment.
Explain the difference between a bactericidal drug and a bacteriostatic drug.Which one would be a better antibiotic for patients and why? Describe the similarities and differences in the drugs penicillin and vancomycin. In your answer describe the targets and mechanisms of action for each. Which would you prescribe to a patient with S. aureus infection and why? Describe the difference between prokaryotic ribosomes and eukaryotic ribosomes. How does this difference allow us to safely target prokaryotic ribosomes? Explain the mechanism...
Describe the differences between the use of the binomial and Poisson distribution. Provide one example of how each can be used and explain why you selected the example.
Explain the differences in mechanism of action potential conduction between non-myelinated and myelinated axons
1.. Example questions to guide you through the mechanism study of Serine proteases Describe substrate binding, including the role and chemical nature of the "specificity pocket" in chymotrypsin, and which peptide bond in the substrate (relative to the specificity group) will be cleaved. Draw the structure of the catalytic triad at the beginning of the reaction, and explain how the states of ionization and hydrogen bonding pattern of those 3 groups change step by step during catalysis. Explain the role...
1.Provide one example of a disparity in health! 2.Provide one example of health equity. 3. Explain the difference between health disparity vs. health equity
Distinguish between the mechanism of cytotoxins and AB toxins and provide one example of each.
1. Describe the four main green solvents. Provide one example of the use of each solvent. (10marks) 2. Describe the Beckman rearrangement of cyclohexanone oxime and the formation of ε‐caprolactamium hydrosulfate. (6marks) 3. Explain how liquid‐liquid biphasic chemistry works and give an example of a biphasic system. (6marks) 4. Describe the problems with fluorous solvents. How might some of these problems be overcome? (6marks) 5. Your supervisor has just told you to synthesize a new chemical. How would you choose...
In your own opinion, explain what is the difference between the Theory of Reasoned Action and the Theory of Planned Behavior? Please provide a public health example that illustrates the differences between both TRA and TRB.