Question

What is the gross level of the disease mechanism of cystic fibrosis? What is the cellular level? Include images for gross normal vs. abnormal as well.

please list GROSS and CELLULAR level.

Answer 1

cystic fibrosis- It is a life threatening and inherited disease which affect our vital organ mainly lungs and digestive system.  

gross level of cyctic fibrosis

Disturbed mutation of the CFTR (cystic fibrosis transmembrane conductase regulator) causes the mucus producing cell to secrete a more thicker secreation due to that in the gross level there will be the blockage of in the organ like lungs , digestive system , pancreas etc

IN LUNGS- as thick mucus is secreated it does not came out with cilia and lung are more suceptible for growth of the bacteria & making it more serious and chronic problem.

IN PANCREASE & DIGESTION- as mutated gene make the secretion thicky and stick, which clogs the pancreas and digestive enzymes doesnt able to get into the intestine due that food is not digested well.  

cellular level of cyctic fibrosis

DNA is made up of 4 building bases when there is a change in the arrangement of the base it causes genes not to work properly and gene start mutating, dring inheritance mutation  of CFTR(CYSTIC FIBROSIS TRANSMEMBRANCE CONDUCTACE REGULATOR ) gene transfer to the CF patient and low or high RNF5 Protien ie. during mutation there is a deletion of phenylaline 508 in CFTR channel which is associate with misfolding and degradation or high expression of mutant protein(RNF5) , now CFTR function as a chloride channel with RNF5 in the cell and chloride channel maintain the level of salt and water within the cell. now in CF patient dysfunctioning of the CFTR gene due the that execcive loss of salt in sweat , mucus in lungs and digesive juice. CFTR genes are not embidded in the cell membrance to make chloride ions the way it should be as a result mucus producing cell secrete thicker than the normal and creates blockage in the vital organ .

CF- cystic fibrosis

CFTR- CYSTIC FIBROSIS TRANSMEMBRANCE CONDUCTACE REGULATOR

HEALTHY A MUCOS um OMDF CELL MEMBRANE RNES CEIR ABNORMAL THICK Mucos CEL MEMBRANE 1 If RNES is T & CFTN Low, CETR function Low/High RNF5 a to little better - If RNES is righ, CETR Channels doesn't work properly & CF patient prone to Infection more