When drugs are administered by intravenous infusion, thus the blood clearance of the drug can be calculated as :
CL = Body clearance rate / Plasma concentration of drug
Here the body clearance rate of drug A is 10.2L/hr
The plasma concentration ratio of drug A is 0.6
Thus we can calculate it as :
= 10.2/0.6
=17ml/min/kg
The total body clearance of drug A is 10.2 Uhr. Calculate blood clearance knowing that plasm...
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Given the following data for Drug A: Plasma Clearance: 4.5 L/hr Blood Clearance: 3.4 L/hr It is correct to say that the plasma to blood concentration ratio is 0.75? True False
A drug has a volume of distribution of 33L and a clearance of 4.3 L/hr. A steady state concentration of 5 mg/L is reached with the administration of 21.5 mg/hr IV-infusion. What is the amount in the body at steady state?
Drug A has a Clearance of S.6 /hr and a half-life of 12 hours. Calculate the volume of distribution in Liters (round to the nearest integer number)
Calculate the hepatic clearance (Umin) of the drug 5-fluorouracil (fus 90%; fex < 196; V-18 L ; t1/2 = 1 1 min.
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The alpha value for a drug in the blood is 0.90, equating to 0.55 ng/mL. What is the concentration of total drug in the blood? The correct answer is 0.61 ng/mL. Please show how this question is solved.
Are these pharmacology questions correct?
16 The volume of distribution of a drug in the body is always equal to which of the following? The total volume of the body The volume of extracellular fluid in the body The volume of water in the body The total volume of the body minus the blood volume None of the above (a) (b) (c) (d) (e) volume of distribution are reported to be 3 hours and 0.25 L/kg respectively. Determine the expected...
We want to calculate the average concentration of a relatively short acting drug in a patient. A bolus of the drug is given quickly via intravenous (IV) and the initial concentration of the drug in the patient is 20 mg/dL. The drug has a half-life of 2 hours. What is the average concentration of the drug in this patient's body over 5 half-lives? Assume first-order kinetics.
1. 2000 mg of inulin was injected into a subject with a total body water of 40 L, blood volume of 6 L (Hct 50%) and interstitial fluid volume of 11 L. What is the concentration of inulin in the blood plasma after equilibration in units of mg%? Round to nearest 0.1