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a volume of distribution of 34 L a total body clearance of 3 uhr, and is 85% bound to plasma proteins. Calculate plasma water
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Answer #1

Name of the drug is Drug A

Volume of distribution is 34 liter

Total body clearance is 3L /hr

85% is bound to plasma protein = 85% of 100 = 85gm

Calculate plasma water clearance for this drug

Volume of distribution = amount of drug in the body / concentration in plasma

Concentration in plasma = amount of drug in the body / volume of distribution

= 85gm / 34liters

= 2.5 gm / L

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