Question

Analyze the role of Vitamin D in bone growth. Include any recent (within the last 5 years) research or controversies regarding Vitamin D supplements. Include the risks of an overdose by the patient

Answer 1

• CALCITRIOL(1,25-dihydroxycholecalcifirol) is the biologically active form of vitamin D.
• It mainly regulates the plasma level of calcium and phosphate.
• vitamin D regarded as sun-shine vitamin.

​​​​​​ROLE OF VITAMIN D IN BONE;

• In the osteoblast of bone,calcitriol or vitamin D stimulate calcium uptake for deposition as calcium phosphate,
• Finally, we know the calcitriol essential for BONE FORMATION,
• Therefore,bone is important reservior of calcium and phosphate.
• Calcitriol+parathyroid hormone increase the mobilization of calcium and phosphate from the bone.
• But it also elevate the plasma calcium and phosphate levels.

RESEARCH OF VITAMIN D SUPPLEMENT:

• on JUNE 19 in JAMA cardiology,result and clinical trials to look whether vit-D supplement associated with reduced risk of cardiovascular disease such as heart attack or strokes
• Finally study done with the 83,000 patients ,

Vitamin-D supplement not associated with any cardiovascular events.

RISK OF OVERDOSE OF VITAMIN D:

• Loss of appetite
• Nausea
• Thirst
• stupor
• Hypercalcemia in particular arteries and kidneys.
• kidney permanently damaged and malfunction.