If you find that a particular gene is deleted in many cancer patients, does this mean...
If you find that a particular gene is deleted in many cancer patients, does this mean that the gene is necessarily going to be a tumor suppressor? Describe your reasoning.
Homework Answers
Cancer usually occurs due to two mutational routes.
1. The first mutation is to make stimulatory gene hyperactive- That usually as dominant effect. One out of two gene needs to be mutated to give this effect. They are called as oncogenes.
2. The second one is make inhibitory gene inactive, It usually has recessive effect and require mutations in both variants of the gene. That gene is called Tumor suppressor gene.
Once a cell transforms into tumor cell, they under go numerous mutations that can be harmful or may not be harmful. So, deletion of one particular gene cannot be always a tumor suppressor gene.
Cancer can also occur due to mutations in two proto oncoenes.
So, a particular gene can be anything that is deleted, it can be an inhibitory sequence that kept proto oncogene silent.
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