Question

This is a biomaterial question can you please show how you get to the answer ?

1. Human osteoblasts were observed to selectively adhere to nanophase Ti6A14V metal implants (ASTM F136, particle size = 0.5.1.4 μm) at the particle boundaries, what is the likely reason for this reported finding?

Answer 1

Titanium alloys allows the bone( osteoblasts) to grow on the surface or down into pores of the implant. When an implant is placed inside the body different biological and physiological reaction occurs across the implant to produce a new bone. This Ti alloys provide strength under physiologic loads to the new bone. Pores which provide an optimal environment for osteoblasts to grow. To enhance the growth pore size is increased. Osteoblast show an increased adhesion and growth on nanophase particle as its grain size is less than 100 nm and having larger pore size. Synthesis of alkaline phosphatase and deposition of calcium-containing mineral are important steps in the proliferation and maturation of osteoblast and it was significantly greater when we culture the osteoblasts on nanophase. So nowadays Ti containing implants in nanophase is used.