Question

Which statement about acetylation is false? a. A protein may be acetylated at the N' terminus by acetyltransferase D. A protein may be acetylated on a lysine R group by an acetyltransferase C. Acetylation is not reversible. d. Acetylation may induce a conformation change in the protein. QUESTION 2 True/False: All proteins that are ubiquitinated are sent to the proteasome and degraded True False QUESTION 3 If a hydrolytic enzyme of the lysosome escapes and enters the cytosol, it will not be active because... the enzyme's conformation is altered to a conformation that is not functional when it is at pH 5 B. the enzyme's conformation is altered to a conformation that is not functional when it is at pH 7. the enzyme has no substrate in the cytosol. D. A and C E. B and C None of the above because the hydrolytic enzyme from the lysosome would be functional in the cytosol.

Answer 1

Answer 1

Option C is incorrect i.e "Acetylation is not reversible".

Explanation

Because acetylation is a reversible process, in the cells HDAC (histone deacetylates) enzymes are present that are responsible for the removal of acetyl groups from the N-acetyl lysine amino acid.

Answer 2

This statement is true i.e "All the ubiquitinated protein are sent to proteasome and degraded".

Explanation

As all the proteins that are targeted for degradation are tagged specifically with the small protein i.e ubiquitine. In the proteasome, these tagged protein gets enter and sequentially degraded.

Answer 3

Option B is correct i.e "The enzyme's conformation is altered to a conformation that is not functional when it is at pH 7".

Explanation

As name suggests hydrolytic enzymes are acid hydrolases enzymes that are active only at acidic pH (approx. 4.8 ) which is found in lysosomes and inactive in cytosol having pH (approx 7.2).