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4. A severe depression of CD4+ T cell subset in man is likely to result in (3pt) (A) Severe depression of humoral immune response (B) Lack of development of skin delayed hypersensitivity reactions (C) Both A and B (D) Neither A nor B (E) Lack of complement

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4. A severe depression of CD4+ T cell subset in man is likely to result in:

B) Lack of development of skin delayed hypersensitivity reactions.

The humoral response (or antibody‐mediated response) mainly involves B cells. Delayed hypersensitivity is a major mechanism of defense against the various intracellular pathogens, and it occurs in transplant rejection and tumor immunity. The loss of CD4+ T cells shows the impaired host response against intracellular pathogens. The bacteria are engulfed by macrophages but are not killed.

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