Question

Explain the possible mechanisms by which Pseudomonas aeruginosa invades and creates biofilms through a quorum sensing.

Answer 1

9:53 PM 44 ..24% ANSWER formation and and that sebent polysace Birtile Formation Pseudomonas aeruginosa is an opportunistic pathogenic bacterium sesparrible los both acute and chenic infections. Beyond its natural resistance to many druge, il ability to Jardim biogfilm, a complexe biological siya.bio, sinalou ineffetive the clearance by immune defense Systems and antibiotherapy. The main key actors relevant in the regulation of biofilm youmather by Pseudomanas aeruginosa inelucling as systemi, Gaes Gede A and Ret sllad S two- component Systems and c-di- GMP - olsperckot polysace bavioles biosynthesis Qs CQuorum Sensing) Syslems and Biofelon, Formation Qs is a cell to cell communication used by many. bacteria to detect their population density by peodwing Andi pesceiving diffusible signal noleules that coordinule virulence factors production, motility and bio film formation. P. aeruginosa possesses two main as System Clas and h1 ) which aluve the peoclu tion and the perception of the Quiloinclucer Signaling moleules N-13-oxo doolecanoy 1)- homosevine laefone (3-%-C12 -HSL) and N-butanoyl-L- homosexine l'olone (C-H51), respectively. A third es I system, based on quinolone signale (pas System), interacts with the acyl homosexine lae toros CAHLs) Systems in an intricele way. 1/1 Rotate Mark Recognize Note

9:54 P M 24% Gresilio Roqulalon by Graes / Geae A ond Rets / hals Two - component Systeme 1. Among the 60 two.. component Systems found in the genome of P. aeruginosa, the Gracs / Gear Å system act as a Super regulator of the Qs System and is involved in the prodlee tion of multiple virulence faitons as well as in bir film formation 1. It is interesting to note that Graed / Gack and Rets/ Lads Systems are proposed to be involved in mecliating the transition 3 the Paruginosa plenotype fum an owle to chenic phase ingestion? c-edi. Gemp. Depenolest polysachariales Biosynthesis and Biogfelmo Formation. polysaccharicel pesebre lies is copenalist on the indsacellelas pool oy bie-(3'5') - Cyclic slimosi'c' guanosine monophosphate (c'din Gosp), a ubiquituous intracellular Srond messenges widely distibut? in batera .To bacterial cells, c-di-. Game is generated from two mo bules of guanosine friphosphate by diguanylale cycloser and becken I down into 2 - Gimp by Specife phosphodies ferases . 2/2 Rotate Mark Recognize Note