12. Please provide the two starting materials for both of the following reactions (A & B...
1. Provide the missing starting materials, reagents, or products in each of the following reactions. H+ OH CH,OH NaOH Meo NH2 room temp. HO OH Meo Me ОН Meo 2. Provide appropriate conditions to convert each of the following starting mana hexanoic acid (some transformations may require more than one step): It each of the following starting materials into OH OH ОMe "NH₂
4. Provide the appropriate starting materials (diene and dienophile) for the following Diels-Alder reactions: CH2CH3 CH2CH3 Heat CO2CHs "Cо-Cна сосн, сосн Heat сосн сосн
3. Provide the reagents necessary to carry out the following reactions or provide the starting materials or major products of the following reactions, Indicate racemic mixtures where necessary. (39 pts) 1)AIC осн, a. Ph 2) PaC H Н,со 45 1) HS0, HNO b. 2) Pd/c. H Н,со он c. Ph HO, он
4.2. Suggest reasonable mechanisms for each of the following reactions. The starting materials are racemic, unless otherwise stated. PhCH,CI + POCH3)3 — PhCH POCH3)2 + CH,CI сн. CH3 CH₂ OH BSCI CHA . CH₂ OH pyridine CH1 but e CH₂ CH₂ BSCI pyridine Bs BsO HC=CCH CH CH CI CF3CO H H percevonova co ,C=CCH2CH2CH2O2CF3 n nousemuannen NH2 TOH NaNO2, H20 NO2, H2 C H=0but (CH3), HCIOTY OH NaNO2, H20 NH, HClO (CH3), HOCH=0 Br CH₂ CH₃ CH₃ CH but...
Q2. Provide the missing information of the following reactions. (such as reagents, starting materials, products_etc.) 21 1. CH,CH-CH=PP 1-Propanol 2-methylpentan-3-one H+, heat H2N Н. + HO- Н HO- + Y. H trace HCI H НО. OH H3C сн. H30.4 H2CH2CO OCH CH3
2. (16 pts) Reactions Provide reagents, products or starting materials for the following reactions. Show stereochemistry when relevant (or loss thereof). If a reaction produces no significant products, write "NR". If you have a question about an abbreviation, just ask. NaBr OH 1. TsCI 2. Nal, DMF CI DMSO OH 1. PBrg NaCN 2. KOC(CH3)3 Ether LDA НОН THE NaH NaH PO Acetone Heat, water
1. Provide the products, starting materials, or reagents. regioselectivity of the reactions. Use filled or dashed wedges, where appropriate. (0.6 pts) Be sure to consider both the stereoselectivity andior 21 H20 H20 [1] (sia)2BH H2SO4 HgSO4 12] NaOH, H202 CH3 2 HCI CH
11. Provide the missing starting materials or reactant for the following reactions. (8 points) Br ????? ???? 222 ????? ?????? CH2OH ogrodowem – Domen OCH3 + ???
Provide examples of 3 reactions that produce compounds containing two new chiral centers from starting materials that contain no chiral centers.
1. The following reactions begin with starting materials of differing stereochemistry yet each provide the same stereoisomer of the product. Explain this observation using an arrow-pushing mechanism. Tsoo- сн,со, CH3CO2H CH,CO, CH3CO2H