How would you develop a subunit vaccine against herpes simplex virus?
A vaccine includes an attenuated or killed antigen injected in the body of the host to boost the immune system whereas a subunit vaccine comprises a part of an antigen that can be a protein or a peptide which are antigenic to boost the immune response.
Subunit vaccine against herpes simplex virus composed of the glycoprotein present in the viral envelope of HSV; it has been seen that this subunit vaccine is effective against both HSV-1 and HSV-2.
How would you develop a subunit vaccine against herpes simplex virus?
Human herpes virus 1 & 2 (herpes simplex virus types 1 & 2) and human herpes virus 3 (varicella zoster virus) share the ability to establish persistence in their host. Discuss the mechanisms of this persistence and describe the disease consequences for each of these viruses.
We briefly discussed the Herpes simplex virus (HSV) recently. I would like for you to write about this virus. Go into some detail about the differences between the two types. Here are a few discussion suggestions you can use during this: –How is it able to lie dormant in someone for years and then resurface again? –How does HSV avoid the immune response during the time it is dormant? –If you are working with the public what do you think...
If a vaccine against the HIV/AIDS virus were available, do you think the global pandemic would eventually be contained
You want to make a live virus vaccine against the COVID-19 virus by using zoonotic coronaviruses, i.e. coronaviruses that currently infect other species and therefore grow poorly in humans. i) What is the advantage of using a virus for the vaccine instead of just injecting spike protein from the COVID-19 virus ii) You obtain the DNA sequence of two coronaviruses that infect bats or foxes. The partial sequence of the spike protein from the human virus, and from these two...
A very popular drug in the treatment of the herpes simplex virus (HSV-1) is called acyclovir. When it comes to the treatment of HIV, the virus that causes AIDS, the most popular drug of choice is AZT (Retrovir). Explain why these drugs are called nucleoside analogues and which nucleotides these are analogues of? (0.5 pt.) Hypothesize how each of these drugs might be affecting the DNA replication of the viruses they are meant to target. Use a drawing to aid...
QUESTION 6 The poly (A) tall on the mRNA of herpes simplex virus is generated by which of the following mechanisms: A. added by the polyadenylation enzyme of the virus B. stealing it from the host mRNAs OC. poliovirus mRNA does not have a poly (A) tail D.added by the polyadenylation enzymes of the host cell E. encoded in the genome QUESTION 7 The poly (A) tail on the mRNA of influenza virus is generated by which of the following...
What approach will you use to develop a vaccine against
cornavirus and why?
Conventional Vs. Evolving Vaccinology Typical features of pathogen Vaccine approach Low antigenic variability Polio Antibody-mediated immunity dominant MMR Tetanus Influenza Diphtheria MenB Licensed vaccines Conventional vaccinology Whole cell vaccines (killed or live attenuated) Subunit Recombinant Conjugate (b) High antigenic variability and/or T-cell-dependent immunity more significant Evolving vaccinology Reverse vaccinology Reverse engineering/ structural vaccinology -omics" GBS Staphylococcus Pneumococcus Chlamydia Gonorrhea Malaria Parasite diseases TB HIV No vaccine available
A virologist has a cell-free extract of herpes simplex virus (HSV) that has a titer of 6 x 10^6 infectious virus particles/mL. This virus forms plaques on monolayers of the monkey kidney cell line, CV-1. Following completion of a 10-fold dilution series, the virologist plates 100uL of each sample in duplicate. Which of the following experimental results did he MOST LIKELY observe in the duplicate plates corresponding to his 1:10000 dilution? TMTC = Too Many to Count (A) TMTC (Plate...
QUESTION 47 Herpes simplex virus is able to avoid the linear replication problem by which of the following mechanisms: A utilizes rolling hairpin replication B. uses the hosts telomerase to complete its genome c. utilizes an RdRp that does not need a primer OD.utilizes rolling circle replication E. does not have a lagging strand QUESTION 48 The mechanism by which the original SARS-coronavirus is thought to have been transmitted to humans is: A. inhaling the urine of deer mice B....
What virus causes the flu? Why doesn't the body produce permanent immunity against that virus? How does the vaccine against the flu work?