Question

You are studying a protein of unknown function in human fibroblasts and make the following observations

                The protein is normally very stable

                When you add a membrane-permeant hormone, your protein suddenly becomes phosphorylated

                Soon after phosphorylation, the protein disappears!

                When the hormone is removed, your protein again accumulates, and is not phosphorylated.

Propose a simple, logical model that explains all of your findings. Use any proteins/pathways that we have discussed since the last exam in your model. If you are unable to think of a model, just explain how the protein disappears only when it becomes phosphorylated (6 pts).

Answer 1

model: - Protein Cno hormone) - Chormone accumulates Phosphorylation degradhan Proker - by protein degration through ubiquinn - proteasome puth way), or - lysosomal proteolysis ) - protein