What effect would treatment of cells with a drug like nocodazole have on the Golgi apparatus?
Homework Answers
Nocodazole is an alkylating agent used in treatment of cancer. It affects the cells by interfering with the polymerisation of microtubules. It depolymerises the microtubules.
Golgi body on the other hand is a stack of cisternae and tubules joined by microtubules. If microtubules are experimentally depolymerised, then the Golgi apparatus loses connections and becomes individual stacks throughout the cytoplasm.
So when cells are treated with a drug like nocodazole, it will disrupt the microtubules. As a result golgi body will be loses its connections and gets dispersed throughout the cytoplasm in the form of golgi ministacks.
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