If you placed some purified C5a at the base of a blister, what effect would you...
- If you placed some purified C5a at the base of a blister, what effect would you expect this to have on local leukocyte traffic. What effect would you expect it to have on blood flow and vascular permeability?
Homework Answers
C5a is activates complement system which is impotantfor immunity and healing. It is a chemoattractant which which increases adhesion molecules on surface of endothelium and increases vascular permeability. C5a also causes release of histamines and it is crucial to promote cell migration migration and adherence of leukocytes, neutrophils and monocytes to vessel walls.
therefore, puting C5a at blister would increase the local leukocyte accumulation at the blister. this means that there is increased blood flow at the place. This will also cause more vascular permeability.
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