Question

For questions 8 and 9, use the following reaction scheme which is part of the B-oxidation of a fatty acid. FAD FADH Compound 2 CoA Reaction A Compound 1 HO Reaction B OH NADH H NAD CoA Compound 4 Reaction C Compound 3 (9 pts) For each reaction A, B and C, shown above, correctly name the type of transformation that occurs during each of the 3 reactions, ie.: name the reaction that is occurring going from compound 1 to 2, compound 2 to 3 and compound 3 to 4. Examples of labels include hydration, dehydration, reduction, oxidation, hydrogenation, dehydrogenation, halogenation, among others. 8. Reaction A: Reaction B: Reaction C 9. (4 pts) Based on the name, B-oxidation, used to describe the metabolism of fatty acids, label the a and B carbons in compound 1 and compound 4 above. 10. (2 pts extra credit pts) Take a close look at the reactions where NAD is involved and is transformed to NADH. What type of reaction is typically associated with NAD? You find examples of this reaction in glycolysis, B-oxidation and citric acid cycle to help you decide. Use the same type of labels as for question 8. 11. (4 pts) Use the information from question 10 to help you predict the product of the following reaction. COo HO-C H HO-C-H coo NAD NADH+H COO

Answer 1

8) reaction A- oxidation , dehydrogenation (removal of hydrogen, loss of electron)

Reaction B- hydration (addition of water molecule)

Reaction C - dehydrogenation, oxidation ( removal of hydrogen , loss of electron)

10) Typically, phosphate addition reaction takes place along with or associated with NAD+ involved reaction, which removes hydrogen and adds phosphate in its place. Along with that dehydrogenation and formation of double bonds.

Date &Canbon S-COA (ompound 1 s-CoA Coo Ho-EH M0-CIH NADT Coo NADH T キnt