In considering active transport by Na+-K+-ATPase, 3 Na+ are pumped out of the cell and 2...
In considering active transport by Na+-K+-ATPase, 3 Na+ are pumped out of the cell and 2 K+ are pumped in for each ATP that is hydrolyzed to ADP + Pi. Given a ΔG for ATP hydrolysis of -10 kcal/mol, and that V is -60 mV (more electronegative inside), and that the pump typically maintains the internal Na+ at 10mM, external Na+ at 145 mM, internal K+ at 140 mM and external K+ at 5mM, what is the efficiency of the pump (i.e., what fraction of the energy available from ATP hydrolysis is used to drive transport)?
Homework Answers
The efficiency of the pump is the energy needs of the pump to move the ions. It is calculated as follows:
Energy required to pump Na+ ions:
Since Na+ is transported against concentration gradient, work must be done, and hence the free energy change is positive.
For K+, the free energy change is calculated as follows:
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In considering active transport by Na+-K+-ATPase, 3 Na+ are
pumped out of the cell and 2...
1. Animal cells have a Na,K pump that couples the energy of ATP hydrolysis to transport 3 Na ions out of the cell and 2 K ions into the cell. Inside astrocytes, the concentration of Na is 20 mM and th...
1. Animal cells have a Na,K pump that couples the energy of ATP hydrolysis to transport 3 Na ions out of the cell and 2 K ions into the cell. Inside astrocytes, the concentration of Na is 20 mM and the concentration of K is 130 mM. The extracellular concentrations of Na and K are 145 mM and 5 mM, respectively. Calculate the energy required for the transport of Na and K , with this stoichiometry; assume that the cell...
The Na+/K+ pump transports 2 K+ into the cell and 3 Nat out of the cell...
The Na+/K+ pump transports 2 K+ into the cell and 3 Nat out of the cell under the use of ATP. Under normal circumstances, the concentration of K+ inside the cell is 140 mm, while the [K] outside of the cell is 6 mM. The concentration of Nat inside the cell is 16 mM, while the [Na] outside the cell is 145 mm. The membranpotential is -0.07 V The temperature is 37°C/310,15K c) Calculate how much energy (kJ/mol it takes...
1a) Which of the following statement is not true for active transport? A Na+/K+ pump is...
1a) Which of the following statement is not true for active transport? A Na+/K+ pump is a form of primary active transport B Requires ATP C transports solutes against their concentration gradient D glucose transporters (GLU transporters) use active transport to transport glucose across the membrane E Na+/glucose co-transport is an example of secondary active transport 1b) Which of the following statement is not true for intracellular and extracellular fluids? A Solute composition of the interstitial fluid is similar to...
(a) For the following conditions, calculate the change in the Gibbs energy associated with transporting 1...
(a) For the following conditions, calculate the change in the Gibbs energy associated with transporting 1 mole of sodium ions from inside to outside the cell. Is work required or produced? Outside: [Na+] = 130 mM [K+] 5 mM Electrical potential = 0 mV [Na+]= [K 110 mM Electrical potential =-70 mV Temperature 25 °C Inside: 10 mM (b) For the same conditions, calculate the change in the Gibbs energy associated with transporting 1 mole of potassium ions from outside...
I need help with C through G please. PeDUL AL U U ULI. Fly. NUVCel 2...
I need help with C through G please.
PeDUL AL U U ULI. Fly. NUVCel 2 8.) The gastric H pump found in the plasma membrane of gastric mucosa cells maintains a cytostolic concentration of K of 145 mM and an H concentration of 3.16 X 10 M. In the stomach, the concentration of K is 10 mM and the Hion concentration is 0.15 M. (A) (2 pts) What is the pH of the cytosol of gastric mucosa cells and...
1. According to the paper, what does lactate dehydrogenase (LDH) do and what does it allow...
1. According to the paper, what does lactate dehydrogenase
(LDH) do and what does it allow to happen within the myofiber? (5
points)
2. According to the paper, what is the major disadvantage of
relying on glycolysis during high-intensity exercise? (5
points)
3. Using Figure 1 in the paper, briefly describe the different
sources of ATP production at 50% versus 90% AND explain whether you
believe this depiction of ATP production applies to a Type IIX
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The Na+/K+ pump transports 2 K+ into the cell and 3 Nat out of the cell under the use of ATP. Under normal circumstances, the concentration of K+ inside the cell is 140 mm, while the [K] outside of the cell is 6 mM. The concentration of Nat inside the cell is 16 mM, while the [Na] outside the cell is 145 mm. The membranpotential is -0.07 V The temperature is 37°C/310,15K c) Calculate how much energy (kJ/mol it takes...
(a) For the following conditions, calculate the change in the Gibbs energy associated with transporting 1 mole of sodium ions from inside to outside the cell. Is work required or produced? Outside: [Na+] = 130 mM [K+] 5 mM Electrical potential = 0 mV [Na+]= [K 110 mM Electrical potential =-70 mV Temperature 25 °C Inside: 10 mM (b) For the same conditions, calculate the change in the Gibbs energy associated with transporting 1 mole of potassium ions from outside...
I need help with C through G please.
PeDUL AL U U ULI. Fly. NUVCel 2 8.) The gastric H pump found in the plasma membrane of gastric mucosa cells maintains a cytostolic concentration of K of 145 mM and an H concentration of 3.16 X 10 M. In the stomach, the concentration of K is 10 mM and the Hion concentration is 0.15 M. (A) (2 pts) What is the pH of the cytosol of gastric mucosa cells and...
1. According to the paper, what does lactate dehydrogenase
(LDH) do and what does it allow to happen within the myofiber? (5
points)
2. According to the paper, what is the major disadvantage of
relying on glycolysis during high-intensity exercise? (5
points)
3. Using Figure 1 in the paper, briefly describe the different
sources of ATP production at 50% versus 90% AND explain whether you
believe this depiction of ATP production applies to a Type IIX
myofiber in a human....
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