Question

ANSWER ALL THE QUESTIONS FULLY AND CORRECTLY!!!

1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules will be reduced in expression - The patient will have an impaired ability to fight viral infections -The patient will have a scarcity of CD8+ cytotoxic T cells 2) A mouse strain possesses a genetic defect and cannot express functioning H-2M proteins (murine equivalent of human HLA-DM proteins). What will be the phenotype of these mice? MHC class I protein chains will still assemble in the ER Mice will not be able to load foreign peptides onto MHC class II molecules CLIP will not bind in the peptide-binding groove Mice will not be able to load self peptides onto MHC class II molecules Mice will have no CD4+ T helper cells Mice will have many self-reactive T cells Ii invariant) chains will stabilize MHC class I molecules Mice will have widespread auto-immune reactions 3) Transgenic mice are manipulated to express already recombined genes for a specific T cell receptor (alpha and beta chains) in their cells. These mice will only possess T cells with these introduced T cell receptors - if their own bone marrow is rendered inactive by irradiation - if their normal T cell receptor genes for alpha chains and beta chains are defective -because of allelic exclusion in beta chain gene expression and positive selection stopping alpha gene segment recombination -if the introduced TCR binds moderately to one of the MHC molecules of the new host