Compare and Contrast the regulation of pyramidine biosynthesis in bacteria and mammals.
Homework Answers
Ans .There are 2 types of nucleosides present in our DNA purine and pyrimidine. Purines are adenine and granine. Pyrimidine are cytosine ,thymine, uracil. Biosynthesis of pyrimidine in bacteria is allosterically regulated at asparate transcarbomylase (ATCase ) .In case of bacteria this ATCase is feedback inhibited by end product CTP. ATP act as signal for both purine sufficieny and energy availability, it is also an allosteric activator of ATCase .ATP and CTP both compete for allosteric site on enzyme. In mammals CSP II catalyses the committed step in pyrimidine synthesis and serves as main point for allosteric regulation .UTP and UDP are feedback inhibitors for CSP II while ATP and PRPP are allosteric activators.
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Compare and Contrast the regulation of pyramidine biosynthesis in
bacteria and mammals.
a. Provide an overview of purine nucleotide biosynthesis and discuss its regulation.
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