Question

Describe the role of homology in prion disease, including its link to the transmissibility of the disease. Also describe why the disease is a slowly progressing disease.

Answer 1

Role of homology in prion disease which includes transmissibility of the disease is to binding hydrophobic region at the molecular level that gives x-ray crystal structures of MO and PrP that binds to the nb484 which is a potential agent for prion diseases that inhibits propagation of proteinase k resistance for such fatal misfolding to through the competitive inhibition mechanism that indications the homology for transmissibility of the disease informing the infectious prion.

Prion disease with some genetic forms progressing slowly over decades because of based on the mutation, clinical phenotype, and also neuropathological features which is referred to as transmissible spongiform that come into contact with the exponential transformation that accumulated with prions that depends on its molecular subtypes.