Question

Describe two ways that degradation of incomplete mRNAs is good for the health of the cell (hint; why is the mRNA incomplete?).

Answer 1

According to the central dogma of biology, we know that from DNA, all types to RNAs are synthesized and from ths mRNA, the ultimate functional proteins are formed.

The formation of incomplete mRNA from the template DNA can be occurred, due to the mutations in the template DNA strands and also for the mis or wrong base base pairing or by the inference of some other mutagenic agents.

If the incomplete mRNA is fromed then the ultimate products the proteins are also become abnormal or mutated.

So, the degradation of incomplete mRNA is good for the health of the cells, because :-

1. The formation of abnormal or mutated proteins from the incomplete mRNA leads to the cellular abnormalities.
2. It can also cause serious diseases within the body of the organisms.
3. Also can form incomplete proteins, those are shows negative effects.
4. They are responsible for death of a cell.  

Thus, degradation of incomplete mRNA, is a amazing repaire mechanism within cells. So our cell can survive and easily detoxify or remove the negative effects. It also prevents the serious diseases. Also eliminate the chance of cellular abnormalities and lethal effects.

Incomplete mRNAs are degraded by the-

• deadenylation by the exonuclease pathways .
• the exosome complex, that degrades mRNAs in a 3′-5′ direction.

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