describe why X chromosome polyploidy is tolerated in humans while polyploidy in other chromosome is not...
describe why X chromosome polyploidy is tolerated in humans while polyploidy in other chromosome is not tolerated? use the example of trisomy 21 to explain why polyploidy is damaging to the normal functionality of the cell.
Homework Answers
X-chromosome polyploidy is tolerated
in humans due to the X-inactivation mechanism
i.e. if a person contains more than one X-chromosome, they will get
inactivated by an epigenetic mechanism.
It is a random process that leaves only one functional X-chromosome
in the cell.
The inactivated X-chromosome = Barr body
Ex: XX = 1 Barr body
XY = 0 Barr body
XXY = 1 Barr body
XXX = 2 Barr bodies
However, excess copies of autosomes do not get inactivated. As a
result, elevated levels of gene products are produced leading to
abnormal phenotypes.
Hence, X-chromosome polyploidy is tolerated than autosomal
polyploidy.
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