Question

QUESTION 33 Which of the following statements about the unfolded protein response (UPR) is true A. UPR activation may reduce the rate of protein synthesis in the cell. B. UPR may be activated when receptors inon the ER sense misfolded proteins. C. None of these statements are true D. All of these statements are true E. Transcription of genes that code for chaperone proteins increases in response to UPR activation. F. Activation of the UPR may induce the production of more ER membrane.

Answer 1

Option D) is correct i.e all of these statements are true.

I Ans. A) UPR activation synthesis in reduce the TRUE may the cell rate of protein B) UPR may be activated when receptors into the misfolded proteins - TRUE ER sense en E) Transcription of genes that code for chaperone proteins increases response to UPR activation True I) Activation of the UPR may induce the production of more ER membrane - TRUE This option D is correct All of these statements are true UPR lumen of to critically It is a cellular stress response which is related to the endoplasmic reticulum (ER) stress UPR is activated in response to accumulation of unfolded or misfolded proteins in the the endoplasmic reticulum. UPR aims to restore normal function by halting protein translation to degrade mis folded proteins to activate those pathways which lead to the increasing production of molecular chaperons. It can also lead to apoptosis activation if stress condition gets prolonged. of the cell 7 T