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Canvas Ā Help Center? biosynthesis of purine nucleotides and thymine metabolism of serine, glycine, methionine, and histidine
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The answer is 1st option - aspartate and 4th option - NH4+

Urea is synthesized in the liver. It is also called carbamide. It is excreted out of the body in urine. Since urea has high nitrogen content, it is used as fertilizer. Urea CO(NH2)2 )  is synthesized from ammonia and carbon dioxide. Urea has two amino (NH2) groups and a joined carbonyl (C=O) group. One nitrogen of the NH2 group comes from the NH4+ (free ammonium ion) and the other nitrogen of the NH2 group comes from the aspartate. So the sources of nitrogen atoms in the urea are aspartate and NH4+.

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