Question

Determine the reagents necessary to carry out each of the following transformations. The reagent choices are listed in the text box above this question (reagents A-K). You will type in ONE letter choice for each reaction from the list above. No reagent set will be used more than once, but not every reagent set will be used. NH 2 CN OH OH Br 5 OH 6 you Reaction 1: Reaction 2: Reaction 3: Reaction 4: Reaction 5: Reaction 6:

Answer 1

Solution:

1. Correct option is K

Benzene is acylated with acetylchloride in presence of Aluminium chloride to form a acetophenone.

2. Aniline is converted into cyanobenzene through diazotization followed by sandmeyer reaction. For diazotization reaction NaNO2 and HCl is used in which amine is converted diazonium hydrochloride salt. Then CuCN is used in sandmeyer reaction in which diazonium hydrochloride salt is reacted with CuCN to replace N2 with CN.

ci NH2 NaNO2, HCI -NEN CEN CuCN

3. Correct option is G

Toluene -CH3 is oxidised to benzoic acid by using KMnO4, NaOH, H2O

4. Correct option is H

Bromo benzene reacted with the magnesium metal thus magesium get inserted between benzene ring and Br, a aryl magnesium bromide is form which then reacted with the epoxide to form a OMgBr complex. The acidification of this complex provided primary alcohol. Then PCC ( pyridinium chloro chromate) is a mild oxidising agent that oxidises primary alcohol to aldehyde.

Br MgBr Mg OMg Br H30+ ОН [ PCC PCC

5. Correct option is E

Bromo benzene is reacted with Magnesium metal to form aryl magnesium bromide in which aryl ( benzene ring) is acts a nucleophile that attacks on aldehyde to form ArOMgBr complex which then acidified to form the alcohol.

OMgBr Br Mg MgBr H30+ OH

6) Phenol proton is abstracted by NaH to form sodium phenoxide. Then it reacted with the ethylbromide to form the phenylethyl ether.