Question

For the following, choose which one of the following statements is FALSE: The Bcl2 family of proteins…

(a) can stimulate apoptosis.

(b) can inhibit apoptosis.

(c) are extracellular signaling proteins.

(d) are intracellular proteins in a pathway.

Answer 1

Solution

Option C is false.

• The Bcl-2 family proteins consists of members that either promote or inhibit apoptosis process so option a and b are true.
• The bcl proteins are localized to the outer mitochondrial membrane of the animal cell where they are thought to form a complex with the voltage-dependent anion channel porin proteins( VDAC1)
• SO here Interaction of Bcl-2 with VDAC1 or with peptides derived from VDAC3 protects against cell death by inhibiting cytochrome c release. A direct interaction of Bcl-2 with bilayer-reconstituted purified VDAC was demonstrated, with Bcl-2 decreasing channel conductance hence this is showing function in intracellular pathways so they are not extracellular proteins.
• So option C is false and d is true.