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A rare mutation on the X chromosome is associated with T- and natural killer-cell lymphoproliferative disorder....

A rare mutation on the X chromosome is associated with T- and natural killer-cell lymphoproliferative disorder. To what extent would the two-hit theory apply to this disease?

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The two hit hypothesis of the lymphoproliferative disorder state that a combination of the T cell non-functioning along with natural killer cells non-functioning lead to the weakened immune system in an individual which further lead to the lymphoproliferative disorder. It means two causes summation lead to the formation of this disorder.

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