Question

Three HIV protease inhibitors are shown below. Assuming they all interact with HIV protease in a manner similar to crixivan (indinavir), circle the atom(s) in the drugs show below that form hydrogen bonds with the Asp25/Asp25' at the enzyme's active site. (3 marks) OH H OH H2N NH он amprenavir nelfinavir он ritonavir

Really stuck on this one, could someone with some comp. Med Chem knowhow please be kind enough and explain how to solve this?

Answer 1

Mechanism of action of protease enzyme is given in the image below:

Mechanism of action of protease inhibitors: