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A chemical messenger uses a G-Protein-linked, cAMP pathway to transduce its signal, which eventually leads to...

A chemical messenger uses a G-Protein-linked, cAMP pathway to transduce its signal, which eventually leads to the activation of enzyme X. Bob has a genetic defect which inhibits GTP hydrolysis in his cells. How would this affect activation of enzyme X?

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The g protein camp pathway depends on the slow hydrolysis of g protein to its subunit. Once g protein coupled receptor is stimulated by enzyme X (in the extracellular), the conformational change will lead to formation of Gs subunit (in the intracellular) to release in exchange of a GDP for GTP. If GTP will not hydrolyse then enzyme X will not be activated in Bob.

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