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certain drugs are commonly used to study mitochondrial respiration. These drugs include Rotenone, oligomycin, and the...

certain drugs are commonly used to study mitochondrial respiration. These drugs include Rotenone, oligomycin, and the mitochondrial uncoupler dinitrophenol. Rotenone inhibits the transfer of electrons from Complex 1 to Uniquinone, oligomycin inhibits Complex 5/ATP synthase by preventing the re-entry of protons into the matrix, and Dinitrophenol leads to the uncoupling of oxidation from phosphorylation of ADP (meaning that less ATP is produced). If you were interested in studying the ATP production through glycolysis only, which of these inhibitors would be most useful? Why?
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Answer:

Drugs mentioned in question are categorised as follows:

  • Electron transport inhibitors
    • Rotenone
    • Antimycin
    • Cyanide
    • Malonate (succinate dehydrogenase inhibitor)
  • Uncoupling agents
    • 2,4-Dinitrophenol (DNP)
    • Carbonyl cyanide p-[trifluoromethoxy]-phenyl-hydrazone (FCCP)
  • Oligomycin (inhibitor of oxidative phosphorylation)

These are not inhibitors of the glycolysis

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