An enzyme catalyzes the following hydrolytic reaction: R-OPO2-OR’ + H2O -> ROPO22- + R’OH Propose a...
An enzyme catalyzes the following hydrolytic reaction:
R-OPO2-OR’ + H2O -> ROPO22- + R’OH
Propose a reasonable mechanism for this reaction in which you explain how Mg++activates the leaving group.
(Answer is C.....but why?)
Select one:
a. It activates the alkoxide to attack the water molecule.
b. It activates the water molecule to attack the phosphorous center.
c. It stabilizes the –OR’ so that the emerging negative charge is neutralized.
d. It stabilizes the ROPO2—so that the emerging negative charge is neutralized.
e. It polarizes the phosphorus oxygen bond so that the water can better attack.
Homework Answers
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An enzyme catalyzes the following hydrolytic reaction:
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