Propose a step by step reaction mechanism with an enzyme catalyst for the conversion of L-Trp to indole, pyruvate an...

Question

Question

NH3 CH2-C-COO 1 H + H2O + CH3-C-COO + NH4 N Tryptophanase Tryptophan Water Indole Pyruvate Ammonium

Propose a step by step reaction mechanism with an enzyme catalyst for the conversion of L-Trp to indole, pyruvate and ammonia.

NH3 CH2-C-COO 1 H + H2O + CH3-C-COO + NH4 N Tryptophanase Tryptophan Water Indole Pyruvate Ammonium

science chemistry

Add a comment Improve this question Transcribed image text

Answer 1

Answer #1

NH3 HO H н. 0 -NH3 0 AZI Hни ZI NH3 NH4 ammonium O enol form indole Keto form

Add a comment

Answer 2

Similar Homework Help Questions

One of the early steps in the citric acid cycle is the conversion of oxaloacetate to...

One of the early steps in the citric acid cycle is the conversion of oxaloacetate to citrate.. see picture for more details 1. One of the early steps in the citric acid cycle is the conversion of oxaloacetate to citrate (see below). Propose a mechanism for this two step process using water and acidic/basic groups on the enzyme as needed (think NAC and NAS) OOC COO S- CoA. CH H20 O -C HO O -C CH citrate synthase CH CH2...
3 pts 4. Identify and write down the (1) Major class of enzymes, (2) Subclass of enzyme? соон соон нo a, -c + —н NA...

3 pts 4. Identify and write down the (1) Major class of enzymes, (2) Subclass of enzyme? соон соон нo a, -c + —н NAD* - о + =c + H+ NADH CH3 CH, Pyruvate Lactate COO соо" + но-сн + + нс H2O NADH H+ CH CH2 -ООС -оос Fumarate L-Malate но н Он + ADP он он НО он он
The bromination of acetone is acid catalyzed: H+ catalyst CH3COCH3 + Br2 = CH3COCH2Br + H+...

The bromination of acetone is acid catalyzed: H+ catalyst CH3COCH3 + Br2 = CH3COCH2Br + H+ + Br– The rates of reaction were determined by measuring the rates of disappearance of bromine using different concentrations of acetone, bromine, and H+ ions, and the following data were obtained at a certain temperature. Rate of disappearance Expt# [CH3COCH3] [Br2] [H+] of Br2 (mol · L–1 · s–1) (M) (M) (M) _ 1 0.30 0.050 0.050 5.9 x 10–5 2 0.30 0.10 0.050...

14. Lactate dehydrogenase (LDH) catalyzes conversion of pyruvate into L-lactate in muscle tissue. What is the...

14. Lactate dehydrogenase (LDH) catalyzes conversion of pyruvate into L-lactate in muscle tissue. What is the AG' (in kJ/mol) for the forward reaction catalyzed by LDH at an average adult body temperature of 37 °C? Equilibrium concentrations of the reactants and products are given below for each of the components. You must show your calculations. (4 pts) 00 0. 0 LDH + NADH + H = - HOCH + NAD 0 CH3 5uM 0.75 UM 7.8 UM Pyruvate 17.5 UM...
The reaction can be speeded up by using a catalyst that reduces the activation energy. The...

The reaction can be speeded up by using a catalyst that reduces the activation energy. The most popular catalysts are based on iron (Fe) and ruthenium (Ru). The table shows the variation in the concentration of N2(g) as a function of time for a reaction carried out at 500 °C and 200 atm in the presence 0 0.2 0.3 0.4 0.5 0.6 of an Fe catalyst: [N,(e)] (mol/L) 2.00 1.68 1.42 1.19 1.01 0.846 0.710 0.1 7. Use these data...
The enzyme carbonic anhydrase catalyzes the reaction CO2(g)+H2O(l)−→−HCO3−(aq)+H+(aq).CO2(g)+H2O(l)→ HCO3−(aq)+H+(aq). In water, without the enzyme, the reaction...

The enzyme carbonic anhydrase catalyzes the reaction CO2(g)+H2O(l)−→−HCO3−(aq)+H+(aq).CO2(g)+H2O(l)→ HCO3−(aq)+H+(aq). In water, without the enzyme, the reaction proceeds with a rate constant of 0.039s−10.039 s−1 at 25°C.25 °C. In the presence of the enzyme in water, the reaction proceeds with a rate constant of 1.0×106s−11.0×106 s−1 at 25°C.25 °C. Assuming the collision factor is the same for both situations, calculate the difference in activation energies for the uncatalyzed versus enzyme- catalyzed reaction.

An enzyme catalyzes the following hydrolytic reaction: R-OPO2-OR’ + H2O -> ROPO22- + R’OH Propose a...

An enzyme catalyzes the following hydrolytic reaction: R-OPO2-OR’ + H2O -> ROPO22- + R’OH Propose a reasonable mechanism for this reaction in which you explain how Mg++activates the leaving group. (Answer is C.....but why?) Select one: a. It activates the alkoxide to attack the water molecule. b. It activates the water molecule to attack the phosphorous center. c. It stabilizes the –OR’ so that the emerging negative charge is neutralized. d. It stabilizes the ROPO2—so that the emerging negative charge...
In the reaction mechanism for the decomposition of formic acid, HCOOH, HCOOH(l) + H+(aq) --> HCOOH2+(aq)...

In the reaction mechanism for the decomposition of formic acid, HCOOH, HCOOH(l) + H+(aq) --> HCOOH2+(aq) HCOOH2+(aq) --> HCO+(aq) + H2O(l) HCO+(aq) --> CO(g) + H+(aq) Which species acts as a catalyst? a. H+(aq) b. CO(g) c. H2O(l) d. HCOOH2+(aq)
1. At what carbon atoms will these aromatics most likely undergo an EAS reaction? Circle them....

1. At what carbon atoms will these aromatics most likely undergo an EAS reaction? Circle them. Can you support your predictions with resonance structures? ÇOH more com- & - 2 2. Provide the curved arrows that interconvert these resonance structures of naphthol. 3. Tryptophan 7-Halogenase is an enzyme that chlorinates tryptophan at an activated position on the aromatic ring. First, the electrophilic chlorine source, HOCI is produced, shown in box 1. Then, a normal EAS mechanism is proposed to take...

Propose a stepwise mechanism for the following reaction of a B-keto ester. Suggest a reason why...

Propose a stepwise mechanism for the following reaction of a B-keto ester. Suggest a reason why this rearrangement reaction occurs. [1] NaOET EtOH [2] H2O* Step [1]: 00: OET OS OCH CH O OH OCHCH CO2CH.CH v DE :0: LOE :: CO.CHCH OCH CH HOCH.CH Step (2]: OE CO_CHCH SH OEt :O: OCH CH3 :: OE: 70: : Et CO2CH2CH3 OCH₂CH₂ Step (3): Et0 :0 OE :0: 19:0: 1 OCH CH O OCH CH3 :0 OE 0 O: Et:0 CO.CH.CH...

Propose a step by step reaction mechanism with an enzyme catalyst for the conversion of L-Trp to indole, pyruvate an...

Homework Answers

Add Answer to:
Propose a step by step reaction mechanism with an enzyme catalyst for the conversion of L-Trp to indole, pyruvate an...

Post as a guest

Earn Coins

One of the early steps in the citric acid cycle is the conversion of oxaloacetate to...

3 pts 4. Identify and write down the (1) Major class of enzymes, (2) Subclass of enzyme? соон соон нo a, -c + —н NA...

The bromination of acetone is acid catalyzed: H+ catalyst CH3COCH3 + Br2 = CH3COCH2Br + H+...

14. Lactate dehydrogenase (LDH) catalyzes conversion of pyruvate into L-lactate in muscle tissue. What is the...

The reaction can be speeded up by using a catalyst that reduces the activation energy. The...

The enzyme carbonic anhydrase catalyzes the reaction CO2(g)+H2O(l)−→−HCO3−(aq)+H+(aq).CO2(g)+H2O(l)→ HCO3−(aq)+H+(aq). In water, without the enzyme, the reaction...

An enzyme catalyzes the following hydrolytic reaction: R-OPO2-OR’ + H2O -> ROPO22- + R’OH Propose a...

In the reaction mechanism for the decomposition of formic acid, HCOOH, HCOOH(l) + H+(aq) --> HCOOH2+(aq)...

1. At what carbon atoms will these aromatics most likely undergo an EAS reaction? Circle them....

Propose a stepwise mechanism for the following reaction of a B-keto ester. Suggest a reason why...

Propose a step by step reaction mechanism with an enzyme catalyst for the conversion of L-Trp to indole, pyruvate an...

Homework Answers

Add Answer to: Propose a step by step reaction mechanism with an enzyme catalyst for the conversion of L-Trp to indole, pyruvate an...

Post as a guest

Earn Coins

Add Answer to:
Propose a step by step reaction mechanism with an enzyme catalyst for the conversion of L-Trp to indole, pyruvate an...