Question

Need help, numbers 3-6 please show work. and fill out table of chemicals for all chemical used.

calculate mmol in the table as well show work please

and each of these must be listed in its own row. There are 10 column headings: IUPAC name OR common name, structure, CAS number (Chemical Abstract Service number) molecular mass, melting point (if applicable), boiling point (if applicable), solubility (in water, if applicable), density, amounts to be used in the experiment, and the role. All chemicals used in the experiment must be listed and include correct units, spelling, amounts and roles (reagent/solvent/drying agent/product). An example of the format for a table of chemicals is shown below: Molecular Melting Boiling Solubility (units) (units) (units) (units) (units) Structure IUPAC or common name CAS # Density mass point point (in water) Amounts to be used Role of the reagent

Answer 1

R 3. R > Nu Nuo RPGX SNZ R Ni: Nucleophile attacker from back side R Effect of nucleophile rate = [new] [ Reactant] The above rate Ega umplis that SNP reaction depends both on the nucleophile as well as on the carbon electrophile Thus, one can make such reactions go better speed ist up or improve its qield) by changing either q reaction Thus, stronger the nucleophilen greater we the mati Orate gletermining is 90° Leaving Group R 1090 leaving R Mu muir Nu PALU Ring ودرم 1200 TS. grp RTR all angles 109° 3anges of 120° Trigonal by pyramis ix angles of 90 The departure of leaving groups us involved in the rate determining step, so, bettle the leaving group, greater the rate of reach Skeletal structure of carben centre As can be seen in the TS, before reach the reactant (carten) has all the bends inclined at 109° but in TS, trigonal bipyran sandal geometry is adopted in which there are 3 angles of 120° and 6 angles of 90°. This arrangement increases the steric hendesans or growding around the reaction centres the substituents R, the more serious this is thus, for, SN² Си-х v. fact R-CM₂-X- fast SN2 R2C1-X sloro R3C-X NO SNR The larger SNR SHOT ON REDMI Y3 AIDUAL CAMERA

Effect of soluent SN2 reactions are generally carried out win aprofi and often less porar solvent CACOCH3 The most common SN2 reactions wol an anion as nucleophile so soluents that fail to solvate anions wuell, make anions (nucleophile mere reactive. this increasing reach rate is more 4. Mechanism : Williamson Ethee Synthesis follows so pathway. Step I Abstraction of acidie H from phenolic moiety of 2-methoxyphenol by Naon, fos, phenolate con nucleophilic than its neutral counter part HC-0. neo SH + H2O (from Noon) Sodium (2-methoxy) phenothide salt o-Nat a 4 STEP I: Attack of sod salt of 2-methoxy phenolate to 3-chloro, 62 propanedio. The phenolate ien chooses the on mootty at Gl because its primany carben and hence deosesleric hinderace and this provides easy approach of it ₂C-of ce | Cho Ои. SHOT ON REDMI Y3 AI DUAL CAMERA

ce Step IIAttack z or from Neon on carbon com containing BOY .out >né Nace ce ou Ои propane 1, 2, 3 trich Stepilttack of phenolate con on the 10 carbon because of less crowd song on и со HEO Tot no on - Guaifenesin any stronger base other than noon ay used it saight have led to Er reaction and also protenation of 3-Ehlero propane 1, 2 dier which would have affected * If any geld more more. SHOT ON REDMI Y3 AI DUAL CAMERA

+ HO I Naon ou Ои T98-216 42 diol m.w with 1 mole 1 more Ston/sho I methoxy phenol 3-chloro propane M. w 124.14 w110.54 Guayenesin Stoichiometrically i mole of 2. metheny phens reacts of 3-chleno propane 1, 2 dior to give of Guaifenesin 124.149 of 1 methoxy phenot reacts with 110. s4 g og 3-chloro propane 1, 2 did to give 198.216 uaifenesin g z guait Come of 2-metheny phend 5mmd=5X10-3 mdles Amount of 2-methony phenol = m wtx no of mores 124-148 5X10-3 g mores of ? 1 3 chlera, 2 propane dio! = 598 m m d = 5-99X10 Pneus Amount used=5.98% 10-3x110-54 used -0-6207 9 0.66 10 36 10 g Now, with 124149.04 2-methery phend meaets 3-chloropropanely 2 clien Ig of 2-methony phend will react with q 3-chleno propane lzdier. 110-54 124.140 igg 0.620720 0.6207 will react with 110.548 124.14 SHOT ON REDMI Y3 AI DUAL CAMERA = 0-55279 % 3 chloro prossene but 3-chloro propene hection res un exen o

limiting methony phenor will act as 80, 2-methoxy reagent 124.14g 2-methony methony phenol gives 198.216 g 7 guarifenesin 0. 6207 9 will X 0.6207 yield =198.216 1 24.14 20.991 20.991 g of guaifenion soo ul 500 x 10-3 me - 0.565 g given Density of 2-metho phend 1.13 glme > in line of sch", 1.13 g cz 2-methong phend by wat is pread Amerent pipetted Amount of 2-methoxyl xhend ing) - 5coxiom 3x113 2-methony phend No. of males = Set of substance rig mwt 0.565 124.14 0.0045513 moles -0.0045513x160o = 4.5513 m micut 124.14 SHOT ON REDMI Y3 AI DUAL CAMERA

Density of 3 chloro 172 propane del = 1:32gline Amount Pipetted = soul Amount in cg, sucked out = 1:32X50x1000 muut of 3-chloro 12 propane did = mo of mores pepetted = 0.66 (109) no sug 110-54 0.00597 moes O-00597x levo = 5.97 mmor- SHOT ON REDMI Y3 AI DUAL CAMERA