Where on the target cells are receptors for peptide hormones usually found and why? Select one:...
Where on the target cells are receptors for peptide hormones usually found and why?
Select one:
A. in the cytoplasm, because (most) peptides act via second messengers
B. in the nucleus, because (most) peptides affect the metabolism of the target cells
C. on the cell membrane, because peptides cannot penetrate the cell membrane
D. on the cell surface, because that is where the G-proteins are located
Homework Answers
C. C. on the cell membrane, because peptides cannot penetrate the cell membrane
- Peptides are hydrophilic (or water soluble) and therefore they con not cross plasma membrane. That's why their receptors are located on plasma membrane. Example - Insulin (a peptide) hormone uses tyrosine kinase receptor (which is located on plasma membrane)
- Steroid hormones are lipophilic (or lipid soluble) and thus can cross plasma membrane easily. That's why their receptor are intracellular - cytoplasmic or intranuclear. Example - testosterone (a steroid hormone) uses intracellular receptor
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