In terms of kidney function, what would be the consequences of the following physiological changes: (write...
In terms of kidney function, what would be the consequences of the following physiological changes: (write consequences for each)
1) Elevated expression of UCP1 in renal mitochondria
2) Mutation causing no Aquaporin 2 expression
Homework Answers
1) Elevated expression of UCP1; which separate oxidative phosphorylation from ATP synthesis by causing proton leak in mitochondria. Thus such in renal mitochondria will be having ATP only from substrate level phosphorylation in Glycolysis and TCA and no ATP synthesis at the electron transport chain level. This will lead to a disruption of the active transport of minerals and ions in kidney cells.
2) Mutation causing no Aquaporin 2 expression will hamper the reabsorption of water in the kidney connecting tubule and collecting duct
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