Question

DI 200 150 Bound [125]]- JRFL (% of wtCCR5) 100 50 CCR5 142F A29S R60S 432 112L C20S AR228 L55Q A73 V C101X C178R S215L R223Q Figure 1. CCR5 binding activity to HIV gp120. Cells were homozygous for alleles shown and each cell type was tested for ability to bind radioactive HIV gp120. Results are shown as a percentage of wild type CCR5 binding activity (Red arrow). Blue arrow depicts CCR5A32 allele. FS299 G301V A335V Y339F Table 1. Allele frequency of natural CCR5 mutations A295 Afro-Americans: 0.015 142F Afro-Americans: 0.007 L55Q Afro-Americans: 0.007 R60S Afro-Americans: 0.013 C101X Afro-Americans: 0.014 S215L Afro-Americans: 0.010 A335V Afro-Americans: 0.025 Y339F Afro-Americans: 0.026

Answer 1

Answer and Explanation:

To know the genotypes of the offspring, the punnet square was made with the parental alleles and from that the probability of particular allele is also found.

3. Mother CC R5 lcroix father CeRS lelole Father ICCRS. Mother clot x CC R5 CERS, CERS CERS, 61018 C1014 CCRS, elox | Cloix, cloix Gonotypes - CCRS (CRS : clolx cloix CCR5 Cloux 25 %. 25 % 50%, LO 4. For homozygous cloix [clox cloix, from the above table it is found that there is 25% chance for the couple will have a child of homozygous Cloix.