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Which metabolic pathway are affected and in which organ in case of fructose intolerance?

Which metabolic pathway are affected and in which organ in case of fructose intolerance?

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Answer #1

Fructose intolerance affects the liver in our body. The disorder occurs in the deficiency of enzyme Aldolase B.

The metabolic pathway to be affected is Fructose-1-phosphate pathway which occurs in liver.

The deficiency of enzyme causes the buildup of F1P in the hepatocytes of liver , causing the blockage of phosphate molecules and hence decreased production of ATP.

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