Question

A. Name three immunodeficiency diseases caused by defects in phagocytes.

B. Which immunodeficiency disease is caused by a defect in the phagocyte NADPH oxidase system, and what is the cellular effect of this defect?

C. What are the main clinical effects of defects in phagocyte function?

Answer 1

Answer A

Immunodeficiencies include
X-linked hyper-IgM syndrome (CD40 ligand deficiency), Common Variable Immune Deficiency (CVID),
X-linked Agammaglobulinemia (XLA),
WHIM syndrome,
Wiskott-Aldrich Syndrome and
GATA2 deficiency.
Some of these patients acquire an autoimmune antibody to their own neutrophils.

Answer B

The Chronic granulomatous disease (CGD) is the immunodeficiency syndrome characterized by a profound susceptibility to bacterial and fungal infection, caused by failure of this oxidase system.NADPH.

Answer C

Phagocyte disfunction is said to a category of medical conditions wherever phagocytes have a diminished ability to fight microorganism infection.
Examples include:
Hyper-IgE syndrome.
Chédiak-Higashi syndrome.
Chronic granulomatous disease