Question

Write a clinical pharmacokinetics note for the chart detailing your plan of action and rationale.

Answer 1

Clinical pharmacokinetics or pharmacokinetics is a branch of pharmacology which is dedicated to determine the fate of substances that are administered within our body. Pharmacokinetics is also abbreviated as PK. The substance whose fate is being studied is called a xenobiotic and those include pharmaceutical drugs, pesticides, cosmetic ingredients etc. Pharmacokinetics can also be called as the organisms effect on the drug in terms of its metabolism to excretion.


The pharmacokinetic properties of any particular chemical that is being taken , depends upon the route of administration of that particular drug, similarly, its adsoption also varies.


After a drug enters into the body, there is an abbreviation that helps with the whole course of the drug inside the body - LADME.
?L- Liberation ( release of the drug from the formulation form)
A- Adsorption ( The substance entering the blood circulation)
D- Distribution ( Dissemination of the substance , throughout the body fluids)
M- Metabolism ( Breakdown of the parent compound into the daughter metabolite)
E- Excretion (Removal of the substance from the body)


Clinical pharmacokinetics can be defined as -
?Clinical pharmacokinetics (arising from the clinical use of population pharmacokinetics) is the direct application to a therapeutic situation of knowledge regarding a drug’s pharmacokinetics and the characteristics of a population that a patient belongs to (or can be ascribed to).?


?Clinical monitoring is caried out by measuring he plasma concentration of the drug at various intervals in order to keep a check on the maximum and the threapeutic levels of the drug. Such data obtained from studying the plasma concentrations is more relialable and thus is used more efficiently. The following can be estimated by clinically studying the plasma concentration:

1) Narrow therapeutic range
?2) High toxicity
3) HIgh risk to life
this can be studied from the graph below :

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