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1)What happens to the post-synaptic membrane potential if you block pre-synaptic Na channels? 2) What happens...

1)What happens to the post-synaptic membrane potential if you block pre-synaptic Na channels?

2) What happens to the post-synaptic membrane potential if you block pre-synaptic K channels?

3) What happens to the post-synaptic membrane potential if you block pre-synaptic Ca channels?

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Answer #1

Ans 1) when presynaptic Na + channels are blocked ,action potential does not generates ,so no change occurs to post synaptic membrane potential .

Ans 2)when presynaptic K+channel is blocked ,action potential has already been generated ,Ca ++ channel opens and there is fusion of synaptic vesicles and release of neurotransmitters .This action potential is transmitted to post synaptic membrane by neurotransmitter and post synaptic membrane undergo depolarisation and post synaptic membrane potential increases .

Ans 3)when pre synaptic Ca ++ channel is blocked , calcium influx does not occur in pre synaptic membrane ,vesicles will not fuse with neuronal membrane ,no neurotransmitters released ,hence no change occurs in post synaptic membrane potential .

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