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Utilizing the external calibrations method, is it possible to extrapolate beyond the calibrated solutions and describe...

Utilizing the external calibrations method, is it possible to extrapolate beyond the calibrated solutions and describe why or why not?

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Preparing a calibration curve , by making a series of standards of known concentrations of analyte, is called external calibration .

It involves a comparison of sample response to the responses to analyte in the calibration standards in a instrumental method.

An example of it is , AAS calibration, in this standards follow Beer’s Law since the relationship between concentration and absorbance is linear.

In this, external calibration method, it is not advisable to extrapolate beyond the calibrated solutions. Since, we only know response of instrument to analyte concentration in the standard range, we don't response of it beyond this range. If we extrapolate beyond this range we may end up getting errors in analysis. As linearity response of instrument varies in different concentration ranges.

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