Question

1) Fosamax has six acidic groups. The structure of the active form of the drug is shown in the figure below. (Notice that the phosphorus atom in Fosamax can be surrounded by more than eight electrons since P is below the second row of the periodic table.)

A)The OH groups bonded to phosphorus are the strongest acids of the six groups. Why?

a) Because phosphorus atom is less electronegative rather than atoms bonded to other acidic groups.

b) Because the atom (P) to which each of the OH groups is attached is also attached to two electronegative oxygens.

c)Because phosphorus atom is smaller than either carbon or nitrogen atom.

d)Because conjugate bases of the OH groups bonded to phosphorus are less stable than that of the remaining groups.

B)Which of the remaining four groups is the weakest acid?

a)group 1

b)group 3

c)group 5

d)group 6

Answer 1

OTH 446 1 9 11:29 AM Fosamax си. -> Weka CH, Hoop ONO + 34,0 Ć-P OH OH Fosoman Structure A The OH groups bonded to phosphorus au the strongest and of the Six groups. Why (6) Because the atom (p) to which each of the Oh groups is at is also attached to two electronegative oxygen. (B). Which of the remaining four groups is the weakest acid? if this is including phosphorus a Hoched on groups So, Right side phosphorus contain ona this is weaker And otherwise carbon chaiN have NH₃ group this is also weakou aad.